The Marvel of Hyaluronic Acid and Kewpie's Pioneering Journey

Hyaluronic acid, a term that has become synonymous with skin hydration, joint health, and overall wellness, has a fascinating history that dates back to the 1930s. This incredible molecule, known for its exceptional water retention properties, has been the subject of extensive research and development, with Kewpie Corporation at the forefront of many groundbreaking discoveries.

A Glimpse into the World of Hyaluronic Acid

Discovered in 1934 by Dr. Karl Mayer of Columbia University, hyaluronic acid was first identified in cow’s eyes. This discovery paved the way for subsequent research that unveiled its ubiquitous presence in various parts of our bodies, including our eyes, skin, and joints.

Hyaluronic acid is a remarkable molecule, a member of the sugar family, composed of two sugars: N-acetylglucosamine and glucuronic acid. These sugars bond in alternating sequences, forming a matrix that can hold vast amounts of water. To put it in perspective, just 1 gram of hyaluronic acid can retain between 2 to 6 liters of water. This incredible water retention capability is what gives our skin its suppleness and freshness.

But the wonders of hyaluronic acid don’t stop at skin hydration. It plays a pivotal role in our eyes, acting as a moisturizer and even aiding in medical treatments like cataract surgeries. In our joints, it serves as a cushion, absorbing shocks and ensuring smooth movement.

Kewpie’s Trailblazing Research on Hyaluronic Acid

Kewpie Corporation, a name that many associate with delightful mayonnaise, has been a pioneer in hyaluronic acid research since the 1980s. Their journey with this molecule is both intriguing and inspiring.

The connection between mayonnaise and hyaluronic acid might seem tenuous at first. However, Kewpie’s initial foray into hyaluronic acid production was influenced by their expertise in egg research for mayonnaise production. In 1985, they began manufacturing hyaluronic acid using the “cock’s comb extraction method.” This method, although effective, was soon replaced by a more innovative approach. Drawing inspiration from the fermentation technology used in vinegar production for mayonnaise, Kewpie developed a “fermentation method” in 2004. This method allowed for the stable production of high-quality hyaluronic acid in large quantities.

Today, Kewpie’s hyaluronic acid manufacturing site buzzes with activity, as passionate researchers and developers work tirelessly to explore the potential of this wonder molecule. They are not just content with what they know; they are continuously prototyping new forms of hyaluronic acid, tweaking its molecular weight and composition to discover novel functionalities.

The Future of Hyaluronic Acid with Kewpie

As we age, our body’s natural production of hyaluronic acid diminishes. By the time we reach our 70s, the amount of hyaluronic acid in our skin is a mere fifth of what it was during infancy. This decline underscores the importance of external supplementation. Recognizing this, Kewpie has been at the forefront of research on the oral intake of hyaluronic acid and its effects on skin hydration.

Moreover, Kewpie’s commitment to innovation is evident in their diverse range of hyaluronic acid products. From penetrating and adsorbing to repairing and knee joint-use products, they offer solutions tailored to various needs. Their vision is clear: to rise to the expectations of their customers and lead the way in developing next-generation functional hyaluronic acid products.


In conclusion, hyaluronic acid is more than just a buzzword in the beauty and health industry. Its multifaceted benefits, from skin hydration to joint health, make it an indispensable part of our lives. And with companies like Kewpie leading the charge in research and innovation, the future of hyaluronic acid looks brighter than ever. Whether you’re looking to enhance your skin’s moisture levels, improve joint health, or simply learn more about this incredible molecule, Kewpie’s pioneering work in the field of hyaluronic acid is sure to inspire and inform.